Biology Department photograph montage

Anne Todgham

Professor Anne Todgham
Assistant Professor
University of British Columbia
At SFSU Since: 
Hensill Hall 437
Office Hours: 
No Office Hours
Office Phone: 
(415) 405-2864
Ecological physiology, environmental genomics, climate change biology





I am an environmental physiologist with an interest in understanding the molecular, biochemical and physiological mechanisms that underlie an animal's capacity to cope with environmental change.  I am fascinated by the diversity of physiological specializations (or strategies) used by animals to tolerate particular habitats that others would find very challenging.  This interest has led my research to investigate how an animal's physiology and environment interact to structure organismal stress tolerance.  My research focuses mainly on marine organisms that are distributed along the California coast (e.g. limpets, sea urchins and intertidal fishes), but extends to New Zealand and Antarctic fishes.  By taking a comparative approach, we are able to understand the differences in tolerance strategies of animals that inhabit variable environments (e.g. rocky intertidal zone) compared to those that inhabit very stable marine environments (e.g. Southern Ocean).  My current research program has an eye towards global climate change and addresses the general question of whether contemporary marine animals have the physiological flexibility necessary to buffer the unprecedented rates of environmental change, specifically ocean warming and acidification.



  1. Hofmann, G.E., Todgham, A.E. 2010. Living in the now: Physiological mechanisms to tolerate a rapidly changing environment. Annu. Rev. Physiol. 72:127-145.
  2. O'Donnell, M.J., Todgham, A.E., Sewell, M.A., Hammond, L.M., Ruggiero, K., Fangue, N.A., Zippay, M.L., Hofmann, G.E. 2010. Ocean acidification alters skeletogenesis and gene expression in larval sea urchins. Mar. Ecol. Prog. Ser. 398:157-171.
  3. Todgham, A.E. and Hofmann, G.E. 2009. Transcriptomic response of sea urchin larvae Strongylocentrotus purpuratus to CO2-driven seawater acidification. J. Exp. Biol. 212: 2579-2594.
  4. Mandic, M., Todgham, A.E. and Richards, J.G. 2009. The evolution of mechanisms of hypoxia tolerance. Proc. R. Soc. B 276:735-744.
  5. Hofmann, G.E., O’Donnell, M.J. and Todgham, A.E. 2008. Using functional genomics to explore the impacts of ocean acidification on calcifying marine organisms. Mar. Ecol. Prog. Ser. 373:219-225.
  6. Sloman, K.A., Mandic, M, Todgham, A.E., Fangue, N.A. and Richards, J.G. 2008. The response of the tidepool sculpin, Oligocottus maculosus, to hypoxia in laboratory, mesocosm and field environments. Comp. Biochem. Physiol. A 149:284-292.
  7. Todgham, A.E., Hoaglund, E.A. and Hofmann, G.E. 2007. Is cold the new hot?: Elevated ubiquitin conjugated protein levels in tissues of Antarctic fish as evidence for cold-denaturation of proteins in vivo. J. Comp. Physiol. B 177:857-866.
  8. Todgham, A.E., Iwama, G.K. and Schulte, P.M. 2006. Effect of the natural tidal cycle and artificial tempeature cycling on Hsp levels in tidepool sculpins, Oligocottus maculosus. Physiol. Biochem. Zool. 79: 1033-1045.
  9. Todgham, A.E., Schulte, P.M. and Iwama, G.K. 2005. Cross-tolerance in the tidepool sculpin: the role of heat shock proteins. Physiol. Biochem. Zool. 78:133-144.
  10. Iwama, G.K., Afonso, L.O.B., Todgham, A.E., Ackerman, P.A. and Nakano, K. 2004. Are hsps suitable for indicating stressed states in fish? J. Exp. Biol. 207:15-19.
  11. Basu, N., Todgham, A.E., Ackerman, P.A., Bibeau, M.R., Nakano, K., Schulte, P.M. and Iwama, G.K. 2002. Heat shock protein genes and their functional significance in fish. Gene 295:173-183.
  12. Todgham, A.E., Anderson, P.M. and Wright, P.A. 2001. Effects of exercise on nitrogen excretion, carbamoyl phosphate synthetase III activity and related urea cycle enzymes in muscle and liver tissues of juvenile rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. A 129:527-539.
  13. Gamperl, A.K., Todgham, A.E., Parkhouse, W.S., Dill, R. and Farrell, A.P. 2001. Recovery of trout myocardial function following anoxia: preconditioning in a non-mammalian model. Am. J. Physiol. 281:R1755-1763.